Scientists create mammalian cells with single chromosome set

Researchers at the University of Cambridge have for the first time created mammalian stem cells containing a single set of chromosomes from an unfertilised Mouse egg in research published in Nature last week.

The technique has previously been used in Zebrafish but this is the first time it has been used to generate mammalian stem cells. The technique should allow scientists to better establish the relationships between genes and their function.

Dr Anton Wutz of the Wellcome Trust said “Any genetic change we introduce to the single set of chromosomes will have an easy-to-determine effect. This will be useful for exploring in a systematic way the signalling mechanisms within cell and how networks of genes regulate development.”

To read the full story from University of Cambridge Research News click here

Leeb M, Wutz A, “Derivation of haploid embryonic stem cells from mouse embryos.” Nature 2011 Sep 7. doi: 10.1038/nature10448 Link

 

Image by Anton Wutz